These side effects may go away during treatment as your body adjusts to the medicine. I found the information and suggest the Puppy see the ER Vet as the main ingredient Naphazoline Hydrochloride is toxic if ingested. 2015/830 and US OSHA HCS 2015 1.1 Product Code: 23774 Section 1. This article is for information only. A conscious rabbit was injected with naphazoline and thereafter with atropine. I.v. Serving Faculty and Staff in Norman, Oklahoma City, and Tulsa campuses. : HY-B0446 CAS No. It works by narrowing swollen blood vessels in the eyes to reduce eye redness. 17852165. Naphazoline (hydrochloride) SAFETY DATA SHEET Supersedes Revision:12/26/2017 according to Regulation (EC) No. Upon ocular administration, naphazoline exerts its effect by acting on alpha-adrenergic receptors in the arterioles of the conjunctiva to produce vasoconstriction, resulting in decreased conjunctival congestion and diminished itching, irritation and redness. Use should be discontinued if symptoms worsen or persist for more than 72 hours. Even a small ingestion can cause clinical signs of vomiting, lethargy/depression or agitation, ataxia (incoordination), hypotension, and a life-threatening low heart rate. Structure. Pharmacokinetics. Immediate veterinary attention should be sought following ingestion. ... Flow-injection chemiluminescence method for the determination of naphazoline hydrochloride and oxymetazoline hydrochloride. In published reports of naphazoline ingestion, clinical effects are hypertension, bradycardia, pallor, diaphoresis, and respiratory distress. Naphazoline belongs to the imidazoline class of sympathomimetics. 2009 May-Jun. Product name : Naphazoline (hydrochloride) Catalog No. Pre-registered substances Substances indicated, in 2009, as being intended to be registered by at least one company in the EEA. 19253271 [Microhemocirculation and its correction in duodenal ulcer during period of rehabilitation]. : 550-99-2 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, manufacture of substances. Drug Name Active Ingredients Strength Dosage Form/Route Marketing Status TE Code RLD RS; NAPHCON-A: NAPHAZOLINE HYDROCHLORIDE; PHENIRAMINE MALEATE: 0.025%;0.3% Human Resources for the University of Oklahoma. Reactive hyperaemia and atrophic rhinitis sicca are well-known local side effects. weakness (severe) Some side effects may occur that usually do not need medical attention. Identification of the Substance/Mixture and of the Company/Undertaking Product Name: Naphazoline (hydrochloride) Product name : Naphazoline hydrochloride CAS-No. Use this medication in the nose as directed. Do NOT use it … The reports on this medication suggest a charcoal lavage to bind the toxins, and supportive care which will include an anti nausea medication and fluids. Naphazoline is an imidazole derivative and a direct-acting sympathomimetic amine with vasoconstrictive activity. Combination of an ocular antihistamine and decongestant. Fortunately, its toxic reactions have been confined to mild local and rare systemic effects.The following case … Accidental poisoning with naphazoline («PRIVINE») hydrochlorid. In case of accidental ingestion, seek professional assistance or contact a Poison Control Center immediately. It is a caustic chemical and highly corrosive, which means it immediately causes severe damage to tissues, such as burning, on contact. Naphazoline HCl prescription and dosage sizes information for physicians and healthcare professionals. In high doses or when ingested, naphazoline can lead to central nervous system … How to use Naphazoline Spray, Non-Aerosol. Symptoms of overdose. 1.3 Details of the supplier of the safety data sheet Company: MedChemExpress USA Tel: 609-228-6898 Fax: 609-228-5909 Am J Dis Child. Due to its α-symphathomimetic effect, this agent has topical and systemic side effects. This medication is used to temporarily relieve eye redness, puffiness, itching, and watering that commonly occur with allergies. Decrease in body temperature. Yamadori Y, Oiso N, Hirao A, Kawara S, Kawada A. Allergic contact dermatitis from dibucaine hydrochloride, chlorpheniramine maleate, and naphazoline hydrochloride in an over-the-counter topical antiseptic. naphazoline are frequently used as local vasoconstrictive and decongestant drugs. Naphazoline is a vasoconstrictor. Hydrochloric acid poisoning. NAPHAZOLINE hydrochloride N. N. R. ("privine hydrochloride") was introduced in 1942; since that time it has become one of the widely used nasal vasoconstrictors. 1948;75(1):76-80. Follow all directions on the product package, or use as directed by your doctor. Naphcon A (naphazoline hydrochloride and pheniramine maleate) is a combination of a decongestant /redness reliever and an antihistamine used for the temporary relief of redness and itching of the eye (s) due to ragweed pollen, grass, and animal dander and hair. It is a vasoconstrictor with a rapid action in reducing swelling when applied to mucous membrane.It acts on alpha-receptors in the arterioles of the conjunctiva to produce constriction, resulting in decreased congestion. 550-99-2 - DJDFFEBSKJCGHC-UHFFFAOYSA-N - Naphazoline hydrochloride [USP:JAN] - Similar structures search, synonyms, formulas, resource links, and other chemical information. drowsiness. Inappropriate use or unintentional ingestion of naphazoline can quickly cause It is a sympathomimetic agent with marked alpha adrenergic activity. Accidental oral ingestion in infants and children may lead to coma and marked reduction in body temperature. Winston C. Hainsworth. Toxicity. : 550-99-2 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratorychemicals, Industrial & for professional use only. Naphazoline Hydrochloride, an ocular vasoconstrictor, is an imidazoline derivative sympathomimetic amine. Naphcon … 1907/2006 as amended by (EC) No. 2008 Mar. Pharmacology, adverse reactions, warnings and side effects. Naphazoline is a medicine used as a decongestant.It is a sympathomimetic agent with marked alpha adrenergic activity. It occurs as a white, odorless crystalline powder having a bitter taste and is freely soluble in water and in alcohol. naphazoline doubled mean arterial pressure (MAP) and reduced heart rate (HR) from 167 to 30 beats/min. The imidazoline derivatives, oxymetazoline, xylometazoline, tetrahydrozoline, and naphazoline, are found in topical ophthalmic and nasal decongestants available OTC. Hydrochloric acid is a clear, poisonous liquid. Acute pulmonary edema associated with naphazoline ingestion. Atropine doubled HR, but caused a marked rise in MAP, too, stressing the adverse effects of atropine in these cases. slow heartbeat. Use of Naphazoline hydrochloride Naphazoline HCl is an ocular vasoconstrictor and imidazoline derivative sympathomimetic amine.Target: Adrenergic Receptorphazoline hydrochloride is the common name for 2-(1-naphthylmethyl)-2-imidazoline hydrochloride. Naphazoline is a decongestant. Substances predicted as likely to meet criteria for category 1A or 1B carcinogenicity, mutagenicity, or reproductive toxicity. Naphazoline hydrochloride Revision Date 19-Jan-2018 Precautionary Statements Prevention Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product Ingestion IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician Rinse mouth Storage Store locked up Disposal 48. In three cases of intentional ingestion of an antiseptic liquid containing naphazoline there was acute pulmonary edema, altered mental status, hypertension, bradycardia, and sweating; two required mechanical ventilation and all of the clinical effects resolved within 24 hours [ 18 ]. There is no antidote for tetryzoline or other similar imidazoline analogue poisoning, but the symptoms can be alleviated and with treatment, death is rare. 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